In “Osteoblastic”, differentially expressed NRs such as NR4A2, NR4A1, NR3C1, NR2F6, NR2F2, NR2F1, VDR, NR1H2, RORA, and THRA among metastasis, primary, and recurrent osteosarcoma tissues (Figure 4). Here, NR3C1 is linked to osteosarcoma.