In “Osteoblastic”, differentially expressed NRs such as NR4A2, NR4A1, NR3C1, NR2F6, NR2F2, NR2F1, VDR, NR1H2, RORA, and THRA among metastasis, primary, and recurrent osteosarcoma tissues (Figure 4). This evidence concerns the gene THRA and osteosarcoma.