In the process of tumor occurrence and development, it often plays an anti-tumor effect at the initial stage, but plays a tumor-promoting function after the tumor colonization progresses (41).Results of a preclinical study showed that blocking TGFβ signaling sensitized tumors to anti-PD-1-PD-L1 therapy in colon cancer mice with liver metastatic disease. Here, TGFB1 is linked to neoplasm.