In clinical studies of hepatocellular carcinoma, it was found that low presence of CD86+ TAM and high presence of CD206+ TAM in hepatocellular carcinoma tumor tissue were associated with advanced clinical stage, poor overall survival (OS) and increased time to recurrence (TTR) significantly correlated, implying a worse prognosis (1).While cell-derived Wnt ligands stimulate M2-like cells to induce TAM polarization through the Wnt/β-catenin pathway, blocking Wnt signaling in cancer cells or Wnt/β-catenin pathway activation in TAM may be a feasible research direction in the future (14–17). This evidence concerns the gene CD86 and hepatocellular carcinoma.