Depleting IL-6 and STAT3 signaling resulted in an accumulation of hepatic steatosis, macrophage recruitment, and increase of hepatocyte proliferation (38).However, there are also different preclinical findings showing that macrophages release IL-6 receptors to induce IL-6 trans-signaling, IL-6 trans-signaling inhibits p53-mediated cell death and activates β-catenin Signaling pathway promotes hepatocellular carcinoma progression in mice (39). This evidence concerns the gene IL6 and hepatocellular carcinoma.