TGFB1 and neoplasm: In previous studies, Tregs characterized by CD25 and FoxP3 expression were found to be potent mediators of immunosuppression in the tumor immune microenvironment, and their presence in the TME was associated with increased metastasis and poor outcome in many malignancies (20, 21).Interaction of T cell receptors (TCRs) with IL-10 and TGF-β signaling promotes the infiltration of Tregs into the tumor microenvironment by modulating the CCL6/CCL20 axis (22).