It was reported that 40.0% of one hundred and twenty-five localized GIST had a p53 alteration, including 20.8% TP53 mutation and 24.8% p53 overexpression, and that the GISTs with p53 alterations were more commonly found in localized high risk GISTs with shorter relapse-free survival. The gene discussed is TP53; the disease is gastrointestinal stromal tumor.