KL and cholangiocarcinoma: To give examples, a study observed that lncRNA SNHG12 enhances CCA growth and metastasis by regulating miR-199a mediated Klotho, which shows potency as a treatment target (24); another study revealed that lncRNA CASC2 targets miR-18a to increase SOCS5 and suppress CCA metastasis and epithelial–mesenchymal transition (EMT) (25).