Based on the importance of lncRNAs engaged in CCA and its potential application for CCA treatment, our previous study applied microarray assay and RT-qPCR validation to explore the comprehensive lncRNA expression profile related to CCA (19), which found a total of 4,223 upregulated and 4,596 downregulated lncRNAs in CCA tissues than in adjacent tissues; furthermore, lnc-PKD2-2-3 not only correlated with ECOG PS, poor differentiation, and advanced TNM stage, but also linked with worse survival in CCA patients. The gene discussed is PKD2; the disease is cholangiocarcinoma.