Our previous study identified a total of 4,223 upregulated and 4,596 downregulated lncRNAs in CCA tissues versus adjacent non-tumor tissues via microarray assay, then verified a key lncRNA (lnc-PKD2-2-3) that not only correlated with advanced tumor features but also promoted stemness and drug resistance in CCA (19). Here, PKD2 is linked to cholangiocarcinoma.