(90)have shown that targeting the EMT inducer CD146 by using engineered black phosphorus nanosheets (BPNSs) and mild photothermal treatment can convert highly metastatic mesenchymal breast cancer cells to an epithelial phenotype, while downregulating mesenchymal markers and upregulating epithelial markers, that is, the EMT in tumor cells is reversed, leading to tumor cell migration to be ceased entirely. This evidence concerns the gene MCAM and neoplasm.