A study proved that when M2-type TAMs were co-cultured with pancreatic cancer cell lines PANC-1 and BxPC-3, it increased the fibroblast morphology of pancreatic cancer cells, with reduced expression of the epithelial marker E-cadherin and increased expression of the mesenchymal markers Vimentin and Snail. This evidence concerns the gene VIM and familial pancreatic carcinoma.