In pancreatic cancer, ARID1A deletion promotes pancreatic tumorigenesis by increasing chromatin accessibility to the enhancer region of aldehyde dehydrogenase 1 family member A1 (ALDH1A1), upregulating ALDH1A1 expression, and attenuating KRAS-induced senescence (35). The gene discussed is KRAS; the disease is familial pancreatic carcinoma.