Hypoxia-inducible factor 1-α (HIF-1α) transcriptionally upregulates the expression of the ectonucleotidases CD39 and CD73 in HCC cells and induces the production of extracellular adenosine (eADO) that significantly promotes pDC recruitment into tumors via the adenosine A1 receptor (ADORA1). The gene discussed is ADORA1; the disease is hepatocellular carcinoma.