The primary tumor secretes some essential soluble molecules such as TDSFs including tumor necrosis factor alpha (TNF-α, TGF-β, and VEGF along with extracellular vesicles (EVs) that are required for the preparation of distant receptive sites for pre-metastatic niche formation and organ-specific metastasis or organotropism (103). The gene discussed is VEGFA; the disease is neoplasm.