In addition, the immunosuppressant effect of NetG1+CAFs are also reflected in the inhibition of natural killer cell-mediated killing of tumor cells, which is controlled by the downstream signaling pathway NetG1, which consists of AKT/4E-BP1, P38/FRA1, vesicular glutamate transporter and glutamine synthase (93). This evidence concerns the gene AKT1 and neoplasm.