In order to verify the relationship between RNF125 and immune infiltration in Colon Adenocarcinoma (COAD), Liver Hepatocellular Carcinoma (LIHC), and Lung Adenocarcinoma (LUAD), we used “TISIDB” website, an integrated repository portal for tumor-immune system interactions, for in-depth immune infiltration analysis. The gene discussed is RNF125; the disease is colon adenocarcinoma.