(41), who showed WNT4 overexpression in all thymoma types; ii) expression of WNT frizzled receptor 6 (FZD6) is stronger in B3 thymomas and TCs compared to other thymomas and NTs; iii) the absence of physiological, age-related decline of WNT4 expression in TETs; iv) a WNT4-driven autocrine loop that activates WNT/PCP/JNK pathway in 3D-cultured neoplastic pTECs; and v) stabilization of JNK activation in neoplastic pTECs through ‘compensatory’ activation of AKT and NF-κB pathways following acute blockade of WNT4 signaling. The gene discussed is MAPK8; the disease is thymoma.