TNFRSF21 and neoplasm: Related studies have shown that necroptosis promotes macrophage-induced adaptive immunosuppression through the co-expression of regulated CXCL1 and Mincle factors, thereby enabling pancreatic tumor progression; DR6-mediated tumor cells induce endothelial cell necroptosis, which in turn leads to tumor cell extravasation and metastasis (25, 26).