As shown in Supplementary Figures S4A, B, tumor tissues showed obviously higher expression levels of CCNE1, CCNB2, TNS4, FGA, CDC20, BUB1B, CENPW, TRIP13, TROAP, TMEM163, KRT6A, and CLDN2 than did the normal tissues. The gene discussed is CLDN2; the disease is neoplasm.