Intriguingly, target genes exhibited significant overlap with genes previously implicated in schizophrenia, autism and intellectual disability including a number of critical players in the maintenance of E/I balance[35] such as ERBB4, CNTNAP2, NRG1, TSC1, UBE3A, CNTNAP4, and DISC1, supporting a convergent role for TCF4 in modulating the known component of the disease risk mechanism[36]. The gene discussed is UBE3A; the disease is autism.