In light of our study suggesting that the NLRP3/caspase-1/IL-1β axis is correlated with inflammatory severity in PM patients and the MHC-I expression is NLRP3/caspase-1/IL-1β axis-dependent in vitro, we assessed the ability of MCC950 to prevent NLRP3 inflammasome activation and to alter the inflammatory response in PM model rats. The gene discussed is NLRP3; the disease is polymyositis.