When FAT1 was mutated, YAP1 was not restrained by phosphorylation, it then acted as an oncogenic driver in HNSCC and contributed to aggressiveness, suggesting that targeting YAP1 may serve as an attractive precision therapeutic option for cancers harboring genomic alterations in FAT1 tumor suppressor genes. The gene discussed is YAP1; the disease is head and neck squamous cell carcinoma.