Interestingly, in a recently completed phase II clinical trial using a combination of HER3 inhibitor CDX-3379 and EGFR inhibitor cetuximab in recurrent/metastatic, HPV-negative, cetuximab-resistant HNSCC, the investigators analyzed tissues from 27 patients including one of two responders. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.