Through a biostatistics/bioinformatics study using HNSCC TCGA proteomic database, we also observed increased cell surface proteins, such as HER3_pY1289, VEGFR2, and PDL1, plus IGFR signaling mediator IRS1 and cell cycle modulator CMYC in more than 90 HNSCC patient samples with FAT1 mutation. The gene discussed is FAT1; the disease is head and neck squamous cell carcinoma.