However, a preliminary TIMER2.0 analysis of TCGA database revealed an inverse correlation of FAT1 expression with infiltration of tumor-inhibiting immune cells (e.g., monocytes and T cells) and a positive correlation with myeloid-derived suppressor cells (MDSCs) in GBM, HCC, cervical and pancreatic cancers, which is also positively correlated with TGFB1/2 expression and eventually results in immune suppression [52]. Here, FAT1 is linked to hepatocellular carcinoma.