Through a biostatistics/bioinformatics study using HNSCC TCGA proteomic database, we also observed increased cell surface proteins, such as HER3_pY1289, VEGFR2, and PDL1, plus IGFR signaling mediator IRS1 and cell cycle modulator CMYC in more than 90 HNSCC patient samples with FAT1 mutation. Here, IGF1R is linked to head and neck squamous cell carcinoma.