LRRK2 and Parkinson disease: Mutations can occur at various locations in LRRK2. To date, eight mutations in LRRK2, including N1437H, R1441 G ⁄H⁄ C, Y1699C, I2012T, G2019S, and I2020T, have been shown to be associated with PD [15, 30, 34].