PKD1 and cyst: The cyst-reducing effect of RGLS4326 was present but blunted in Pkd1RC∆17/- or Pkd1RC/-; Pkd2∆17/∆17 cell lines, suggesting that this compound mediates its benefits in Pkd1RC/- cells primarily via Pkd1/2 derepression (Supplementary Fig. 14d-g).