Surprisingly, we noted that PC2 derepression was associated with reduced 3D cyst growth, restored MitoTracker signal, and downregulation of pCreb1, Yap1, Mettl3, and c-Myc expression in Pkd1RC/-; Pkd2∆17/∆17 cells compared to Pkd1RC/- cells (Fig. 4b-d and Supplementary Fig. 11b-c). The gene discussed is YAP1; the disease is cyst.