Consistently, we observed that compared to Pkd1RC/-; Pkd2+/+ kidneys, Pkd1RC/-; Pkd2∆17/∆17 kidneys exhibited reduced c-Myc and Yap1 expression (Fig. 4G) and lower cyst proliferation and interstitial inflammation (Fig. 4j). This evidence concerns the gene YAP1 and cyst.