INS and obesity due to melanocortin 4 receptor deficiency: Some of the potential side effects of conventional antidiabetic drugs include hypoglycemia, gastrointestinal tract disturbance, weight gain, skin rash or itching (sulfonylureas); kidney complications, stomach upset, lethargy, metallic taste (biguanides/metformin); flatulence, bloating and diarrhea (alpha-glucosidase inhibitors); liver disease, weight gain, anemia, arthritis (thiazolidinediones); obesity, hypoglycemia (meglitinides); lipodystrophy, hypoglycemia, dizziness, confusion, mood changes, tingling sensations, headaches (insulin-s.c [subcutaneous injections]).3