APOC3 and Hyperinsulinemia: Liver APOC3 knockdown did not affect the development of the lipodystrophy syndrome (Supplement Figure 5(D)), overall body weight (Supplement Figure 5(E)), or development of hyperglycemia, hyperinsulinemia (Figure 6(D)–(F)) or glucose intolerance in Ai-DKO mice (Supplement Figure 5(E)).