Interestingly, when IR or both IR/IGF1R are deleted in mature adipocytes of adult mice using an adipocyte-specific tamoxifen-inducible Cre, the resultant mice exhibit rapid adipose tissue loss and a similar metabolic syndrome, but in this case, the phenotype is transient, reaching its maximum at 3–6 days following completion of the tamoxifen treatment, after which there is a gradual reversal of these features over the following 10–30 days. This evidence concerns the gene INSR and metabolic syndrome.