Neutropenia can be managed with dose reductions and holds until the event is resolved as indicated in the approved labels (Table 1).9, 10, 11, 12, 13, 14, 15 Duration and severity of neutropenia may also be reduced with the use of granulocyte colony-stimulating factor (G-CSF), which aids in white blood cell production within the bone marrow.42 Here, CSF3 is linked to neutropenia.