Considering previous COVID-19 infection, the spike peptide pool induced a higher IFN-γ production in COVID-19 recovered individuals than in naïve subjects in both groups (controls: median 859 pg/ml in recovered patients vs. 445 in naïve; p 0.017, and RD patients: 849 in recovered vs. 278 in naïve; p 0.024). The gene discussed is IFNG; the disease is COVID-19.