Compared with the MN T1DM group, IFN-γ expression in CD4+ T cells was remarkably reduced (p < 0.0001), but IL-4 expression in CD4+ T cells was significantly increased (p < 0.001) in the STAMP-treated T1DM mice, indicating Th1 to Th2 response shift. Here, IL4 is linked to type 1 diabetes mellitus.