We had designed the molecularly imprinted polymers instead of nNOS and PSD95 as receptors to capture several uncouplers from complex samples like the extracts of natural medicines and Sanhuang Xiexin Decoction, whose potential dissociation of PSD95 and nNOS to treat stroke was demonstrated by the experiments on glutamate-injured PC12 cells and MCAO/R (middle cerebral artery occlusion and reperfusion) rats in vivo [14–16]. The gene discussed is NOS1; the disease is stroke disorder.