Further, we demonstrated that SAHH inhibition significantly weakened the favorable effects of normal BMSCs on diabetic cardiomyopathy, while the transplantation of diabetic BMSCs with SAHH overexpression promoted the recovery of heart function in diabetic cardiomyopathy partly by the activation of Nrf2-mediated antioxidant signal. This evidence concerns the gene AHCY and diabetic cardiomyopathy.