We evaluated insulin sensitivity and change of cytokines including adiponectin, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in obesity and normal body weight TNBC patients, studied influence of cytokines secreted by insulin resistant adipocytes to tumor proliferation and migration in TNBC cell lines. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.