DNASE1 and Posterior Leukoencephalopathy Syndrome: Interestingly, although the direct contribution of these mutations in Case 4 presenting with various autoantibodies, proliferative LN and seizure associating posterior reversible encephalopathy syndrome remain unknown, reduced plasma DNase1 activity have recently been shown to cause the persistence of pro-thrombotic neutrophil extracellular traps, promote microvascular thrombosis and contribute the development of TMA [57].