PLOD1 and polycystic ovary syndrome: Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disorder of women and is characterized by a clustering of hyperandrogenism, hypersecretion of luteinizing hormone (LH), and hyperinsulinemia, affecting approximately 9–18% of reproductive-aged women depending on definitions and the populations studied [1, 2].