A study showed that the elevated basal day 2/3 LH levels and LH/FSH ratio do not impair the outcome of GnRH antagonist protocol-treated IVF/ICSI cycles in patients with PCOS [15], which illustrates that suppressing LH values before IVF is not clinically worthwhile for individual patient management. This evidence concerns the gene GNRH1 and polycystic ovary syndrome.