Drug-specific T-cell receptors (TCRs) have been observed in oligoclonal T cell populations isolated from skin lesions and blood samples of allopurinol-induced SCAR patients with HLA-B*58:01 allele [10] and carbamazepine-induced SJS/TEN patients with HLA-B*15:02 allele [11]. Here, HLA-B is linked to toxic epidermal necrolysis.