Furthermore, we found that HM13 expression was an independent prognostic factor for HCC patients by Cox proportional regression model in TCGA (Fig. 5B, p < 0.05), ICGC (Fig. 5C, p < 0.05), and clinical sample cohort (Fig. 5D, p < 0.05). This evidence concerns the gene HM13 and hepatocellular carcinoma.