In inverse variance weighted (IVW) MR, we identified at a false discovery rate (FDR) of 5% nineteen blood proteins that were significantly associated with HF (ABO, BAG3, FLT4, TDGF1, FUT3, FSTL1, ALDH3A1, GLCE, PTHLH, CDON, FCGR2A, RGMB, AMH, MIF, IL15RA, B3GAT3, CCDC126, ST3GAL6, APOA5) (Fig. 1) (Suppl. The gene discussed is APOA5; the disease is hydrops fetalis.