Consistent with the present data, activin-mediated signaling (ActRII) in cardiomyocyte promoted the degradation of sarcoplasmic reticulum Ca2 + ATPase (ATP2A2 also known as SERCA2), an important regulator of cardiac contractility, and the development of aging-related HF in a rodent model [49]. The gene discussed is INHBE; the disease is hydrops fetalis.