Among the causal candidates, 7 (ABO, FLT4, PTHLH, MIF, IL15RA, B3GAT3, CCDC126) were positively associated with HF, whereas 12 (BAG3, TDGF1, FUT3, FSTL1, ALDH3A1, GLCE, CDON, FCGR2A, RGMB, AMH, ST3GAL6, APOA5) were negatively associated with the risk of HF. This evidence concerns the gene FLT4 and hydrops fetalis.