Taken together, these data suggest that according to the directional effect MIF, FLT4, PTHLH, ABO, CCDC126, IL15RA, and B3GAT3 (blood proteins positively associated with HF) are potential targets for HF as they are the object of approved, in-development inhibitors or deemed tractable for the development of novel inhibitors (antibodies). Here, B3GAT3 is linked to hydrops fetalis.