In MR, the 12 proteins (ABO, TFGF1, GLCE, CCDC126, IL15RA, FCGR2A, CDON, FUT3, ST3GAL6, B3GAT3, ALDH3A1, FLT4) remained significantly associated with HF (FDR < 0.05) with concordant directional effect (Suppl. The gene discussed is CDON; the disease is hydrops fetalis.