Among the causal candidates, 7 (ABO, FLT4, PTHLH, MIF, IL15RA, B3GAT3, CCDC126) were positively associated with HF, whereas 12 (BAG3, TDGF1, FUT3, FSTL1, ALDH3A1, GLCE, CDON, FCGR2A, RGMB, AMH, ST3GAL6, APOA5) were negatively associated with the risk of HF. The gene discussed is CCDC126; the disease is hydrops fetalis.