In weighted median MR, which is robust to invalid instruments [20] (variants with horizontal pleiotropy), 17 blood proteins (ABO, BAG3, CDON, APOA5, CCDC126, FLT4, IL15RA, ALDH3A1, PTHLH, RGMB, AMH, GLCE, TDGF1, FSTL1, FCGR2A, B3GAT3, MIF) remained significantly associated with HF (Suppl. This evidence concerns the gene GLCE and hydrops fetalis.