IL1B and schizophrenia: Moreover, Lang et al. refer to several genes that lead to immune signaling deficits by correlating them with schizophrenia, such as DISC1 scaffold protein, regulator of G protein signaling 4 (RGS4), proline dehydrogenase 1 (PRODH), DiGeorge Syndrome critical region gene 2, and 6 (DGCR2 and DGCR6) and zinc finger DHHC-type palmitoyltransferase 8 (ZDHHC8), V-akt murine thymoma viral oncogene homologue (Akt), cAMP response element-binding protein (CREB), IL-1B, IL-1RN, and IL-10 [238].