Some evidence shows that there is an association between schizophrenia and allele A or G of TNF-α − 308 G/A [242] as well as Hasan et al. demonstrated that TNF-α − 238 G/A and − 308 G/A polymorphisms are not associated with schizophrenia but TNF-α − 238 G/A polymorphism may be related to treatment resistance and attempted suicide in patients with schizophrenia. The gene discussed is TNF; the disease is schizophrenia.