In keeping with this, acceleration of cell proliferation could be observed in established and primary cell lines regardless of their background and upon either transient or stable knockdown of FGFR4. Accordingly, gene programs related to cell cycle and proliferation were highly enriched in the comparison between low versus high FGFR4 tumours of the ICGC and PanCuRx cohorts [3, 5]. Here, FGFR4 is linked to neoplasm.