We found the significant enrichment of gene sets related to the PI3K/AKT, ERBB, Axon guidance, and RAS signalling pathways in PDAC cells depleted for FGFR4 (Fig. 6A, Supplementary Table 8) as well as in the FGFR4low tumours of both the ICGC [3] and PanCuRx [5] cohorts (Fig. 6B, Supplementary Table 8). The gene discussed is EGFR; the disease is neoplasm.