TDP-43 suppresses the cell apoptosis of HCC through the lipid metabolism-related gene ABHD2. Molecular mechanism investigation reveals that TDP-43 can bind to the 3ʹUTR of ABHD2 mRNA and enhance the stability of ABHD2 mRNA, thereby upregulating the expression of ABHD2. The gene discussed is TARDBP; the disease is hepatocellular carcinoma.