Mechanistically, for patients in high coal-consumption regions, the level of dibenzoanthracene, a member of the polycyclic aromatic hydrocarbon family, increase, which therefore promoted the transcription of lncRNA CAR10 by FoxF2 in lung cancer epithelial cells, and the expression of CAR10 upregulated EGFR signaling pathway thereby promoting cell proliferation and inducing tumorigenesis [19, 20]. This evidence concerns the gene ADAM12 and lung cancer.