Based on cell line experiments, five abnormally expressed lncRNAs were found in the gefitinib-resistant NSCLC cell line, including three highly expressed lncRNAs (UCA1, NE AT1, CA SC 9) and two low-expressed lncRNAs (EWA ST1, linc00524). The gene discussed is UCA1; the disease is non-small cell lung carcinoma.