To better understand the HNRNPC downstream regulation, we first conducted RNA-seq analysis of stable HNRNPC KD and negative control (NC, scrambled insert) oral cancer cells (Fig. 4A), which identified that HNRNPC-KD resulted in dysregulation of 1180 genes (609 up- and 571 downregulated) (Supplementary Table S4). This evidence concerns the gene HNRNPC and lip and oral cavity carcinoma.