In addition, BA could also activate the adenosine 5′-monophosphate-activated protein kinase (AMPK)/mitochondrial fission pathway to elicit apoptosis and autophagy.123 Hexokinase 2 (HK2) is overexpressed in human cancers, accelerating glucose uptake and forming the HK2-VDAC complex to generate apoptosis resistance.124 Liu et al. found that xanthohumol exerted a significant antitumor effect on CRC cells by downregulating HK2 expression and suppressing glycolysis. This evidence concerns the gene HK2 and cancer.