TLR4 and Familial prostate cancer: The natural product Curcumin inhibits the survival of breast cancer cells by inhibiting the TLR4-dependent TICAM1 signaling pathway, reducing the level of interferon (IFN-α/β).322 Nobiletin (NOB), an O-methylated flavonoid, inhibits the growth of different types of prostate cancer cells to varying degrees by inhibiting TLR4/TICAM1/IRF3 and TLR9/IRF7 signaling pathways, depending on hormonal status and aggressiveness characteristics.323