For example, chloroquine can induce lysosomal membrane permeability to regulate lysosomal function, so as to restore the sensitivity of refractory non-small cell lung cancer cells to cisplatin;412 Azithromycin (AZM) can increase the expression of lysosomal galectin-3 spots, enhance the permeability of lysosomal membrane mediated by lansoprazole (LPZ), and significantly enhance the death of cancer cells induced by LPZ.413 These findings suggest that cancer cells that are not sensitive to traditional therapy may be effectively treated by using activated lysosomal cell death pathway. This evidence concerns the gene LGALS3 and cancer.