MTOR and ovarian carcinoma: The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin PI3K/Akt/mTOR pathway is one of the most important signaling pathways regulating cell progression,193 which is overactivated in the occurrence and development of cancers194 PKI-402 was a dual PI3K/mTOR inhibitor that inhibited the growth of cisplatin-resistant ovarian cancer epithelial cell SKOV3.