PARP1 and colorectal cancer: The mechanism is that downregulating the level of PARP-1 protein can inhibit the activity of NF-κB and the expression of tumor-promoting related proteins regulated by NF-κB and inhibit the occurrence of parthanatos.387 In addition, PARP-1 knockout mice could significantly reduce the incidence of colorectal cancer induced by oxymethane (AOM) combined with dextran sulfate sodium (DSS).