MAPK8 and neoplasm: A study studied the antitumor effect of NEC-1 through colitis associated cancer (CAC) mouse model and considered that NEC-1 can significantly inhibit tumor growth and development by inhibiting JNK/c-Jun signal pathway.302 At the same time, several necrostatin related compounds with necroptosis inhibitory activity, including NEC-3, NEC-4, NEC-5, NEC-7 and so on, have been gradually studied in depth.