MTOR and colonic neoplasm: Besides, LYN-1604 activated ULK1 with a median effective concentration (EC50) value of 18.94 nm in an in vitro kinase assay.219 Liu et al. found that a dual PI3K/mTOR, NVP-BEZ235, promoted autophagy colon cancer cell death via the upregulation of the AMPK/ULK1 pathway.220 Disulfiram (DSF) was an anti-alcohol drug that could suppress malignant tumor growth.