The upregulation of ACSl4 is the sign of ferroptosis.293 On the contrary, some antioxidant systems, especially the XC system (including core component SLC7A11), GPX4, NFE2L2, and some heat shock proteins (such as HSPs), inhibit the ferroptosis lipid peroxidation process.293 The ultimate goal of clarifying the potential mechanism of ferroptosis is to obtain better cancer treatment options. The gene discussed is NFE2L2; the disease is cancer.