TLR4 and neoplasm: One study showed that the TICAM1 (rs8120) gene in PTC was associated with SNPs.321 In addition, there was a significant interaction between TICAM1 (rs8120) and FOXE1 (rs10984377), a known susceptibility locus for thyroid cancer, suggesting that multiple RCD mechanisms and host factors may interact in complex ways to increase the risk of PTC and FTC.321 TLR4 is overexpressed in breast tumors, thereby promoting tumor progression and metastasis.