TP53 and acute lymphoblastic leukemia: Besides, APG-115 combined with radiosensitivity could enhance the antitumor activity both in vitro and in vivo.162 HL001 was a Cyclophilin A (CypA) inhibitor, which restored the expression of p53 by suppressing the MDM2-mediated ubiquitination of p53, thus inducing the cell cycle arrest and apoptosis of NSCLC cells.163 Similarly, anthraquinone (AQ) analog, AQ-101, promoted the apoptosis of acute lymphoblastic leukemia (ALL) cells via downregulating the MDM2 level to activate p53 protein.164