TP53 and cancer: When ferritin nanoparticles are swallowed by cancer cells, the nanosystem can release erastin and rapamycin to inhibit systeam Xc− and autophagy, respectively, resulting in ferroptosis in tumor cells.479 In addition, the organic metal network (mon-p53) wrapped with p53 plasmid combined with iron can also induce the occurrence of ferroptosis by releasing iron and p53 plasmid to inhibit systeam Xc−.