These cell lines cover almost all common cancer types, especially colorectal cancer cells and hematopoietic system tumors, which are more sensitive to necroptosis inducers.294 Necrostatin-1 (NEC-1) is a specific inhibitor of necroptosis by preventing the interaction between ripk1 and ripk3, which can specifically inhibit necroptosis without affecting normal cell function and apoptosis. The gene discussed is RIPK3; the disease is colorectal cancer.