Major bioactive curcumin derived from the rhizome of Curcuma longa induces necroptosis and apoptosis by increasing cleaved caspase-3 and cleaved PARP, p-RIP3, and p-MLKL proteins and finally reduces the viability of tolerant prostate cancer pc-3act cells.310 Arctigenin, a mitochondrial complex I inhibitor, induces necroptosis in prostate cancer cells through ROS-mediated mitochondrial damage and increased CCN1 levels, ultimately increasing p-RIP3 and p-MLKL levels. Here, CCN1 is linked to prostate cancer.