It could block the cell cycle at the G2/M phase and induce apoptosis through the activation of p53 and PTEN, further promoting the expression of Bax and Cyt-C.175 It was also found that indolizine derivatives, compound 3, and resveratrol derivative, trans-3, 5, 4′-trimethoxystilbene (TMS), promoted the activation of p53, causing the apoptosis of cancer cells.176,177 TMS cotreatment with TRAIL could reverse the resistance to apoptosis in cells.177. This evidence concerns the gene TP53 and cancer.