YIPF2 facilitated chemotherapeutic drug-mediated apoptosis by promoting TNFRSF10B cell membrane circulation in NSCLC.66 ASTX660 as a cIAP1/2 and X-linked inhibitor of apoptosis protein (XIAP) antagonist could sensitize murine oral cancer (MOC1) cells to TNF-α and induce apoptosis of TNFR superfamily downstream cells. The gene discussed is YIPF2; the disease is non-small cell lung carcinoma.