PYGL and neoplasm: Resibufagenin induces CRC cell necroptosis by inducing RIPK3 mediated activation of glycogen phosphorylase (PYGL), glutamine synthetase (GLUL), and glutamate dehydrogenase (GLUDL) so as to inhibit tumor growth.303 It shows that RIPK3 is not only a molecular switch of necrotic cells but also a hub to control the metabolic state of cells.304,305 Some complexes have been proved to induce necrotic apoptosis of tumor cells and play an antitumor role, but they are still limited to basic research.