TRAIL has been shown to selectively induce apoptosis in various tumor cells without affecting normal cells.52 In this report, Shishodia et al. found that tetrandrine (TET) could sensitize resistant and mildly sensitive prostate cancer cells to TRAIL-induced apoptosis, and these effects were regulated by upregulating the messenger ribonucleic acid (mRNA) expression of DR4/DR5.53 ONC201, a TRAIL-inducing compound expressed the potential anti-cancer activity in numerous cancer cell lines. The gene discussed is TNFRSF10B; the disease is cancer.