Although RIPK3 and MLKL appear to be common players in necroptosis, but RIPK1 is not involved in TLRs-mediated necroptosis.317 TLRs are commonly expressed in innate immune cells and tumor cells.318 TLR ligands mediate RIPK3-MLKL-dependent necrosis through TICAM1(also known as TRIF). This evidence concerns the gene MLKL and neoplasm.