BAX and non-small cell lung carcinoma: It facilitated the expression of procaspase 8, FasL/Fas, and TNF-α to activate the extrinsic pathway and upregulated Bax, downregulated Bcl-2, thereby releasing Cyt-C to activate the intrinsic pathway.65 In non-small cell lung cancer (NSCLC) cell lines, after pemetrexed treatment, the expression of TNFRSF10B and a vesicular trafficking regulator protein, yip domain family 2 (YIPF2), was increased.