This combination could modulate endoplasmic reticulum (ER) stress, suppress the β-catenin pathway, induce cell arrest at the G2M phase, and thus induce CRC cells’ autophagy and apoptosis.452 Recently, flubendazole and 5-FU had been found to synergically inhibit cell proliferation and promote cell death by targeting p53 protein and activating ferroptosis.453 As we all know, dietary polyphenols could be used as a chemical sensitizer to enhance drug efficacy and reduce chemotherapy resistance. This evidence concerns the gene TP53 and colorectal carcinoma.