WEE1 inhibitors play a key role in the treatment of tumors.456 Combined inhibition of BET and WEE1 could synergistically attenuate the growth of NSCLC cells.457 Besides, the study had shown that BET inhibitor increased WEE1 inhibitor AZD1775-induced DNA double-strand breaks and cytotoxicity. This evidence concerns the gene DNER and non-small cell lung carcinoma.