It could be an effective therapeutic strategy for overcoming multidrug resistance in cancer cells.139 Radiotherapy was the main treatment for non-small cell carcinoma, while radioresistance would be induced, leading to a low reactivity.140 The research showed that isorhamnetin (ISO), a flavonoid extracted from Hippophae L., could be a potent natural radiosensitizer to increase the incidence of apoptosis, the change of MMP, as well as suppress the upregulation of NF-κB p65 triggered by irradiation in A549 cells. The gene discussed is NFKB1; the disease is cancer.