Shikonin, a naturally occurring naphthoquinone sensitive breast cancer cell line, and drug-resistant cell line, showed the same necroptosis, which proved that shikonin avoided the apoptosis resistance mediated by p-glycoprotein, Bcl-2 and Bcl-xL by inducing necroptosis of drug-resistant cancer cell lines, thereby inhibiting drug resistance.332. The gene discussed is BCL2; the disease is cancer.