Upon certain stimuli, IκBα is phosphorylated and degraded in a proteasome-dependent manner, which releases NF-κB and ultimately transfers to the nucleus, regulating the transcription of target genes, thus affecting the occurrence and development of tumors.132,133 Blocking the activity of NF-κB could change the survival/death balance of tumor cells. The gene discussed is NFKB1; the disease is neoplasm.