Pretreatment with the necroptosis inhibitor necrostatin-1 restored their levels and prostate cancer cell viability.311 Ophiopogonin D’ (OPD’), a natural compound extracted from Ophiopon japonicus, induces significant necroptosis in androgen-dependent LNCaP cancer cells by activating and increasing Fas ligand (FasL)-dependent RIPK1 protein expression and exerts antitumor effects.312. The gene discussed is RIPK1; the disease is cancer.