TP53 and cancer: In mice with cancer, mon-p53 treatment not only inhibited tumor growth but also prolong the life of mice.480 In addition, a novel cascaded copper-based metal-organic framework therapeutic nanocatalyst using HKUST-1 amplifies the treatment of hepatocellular carcinoma by integrating the cyclooxygenase-2 (COX-2) inhibitor meloxicam and the chemotherapeutic drug sorafenib.481 In recent years, a variety of regulatory cell death forms have been found and characterized by their corresponding molecular mechanisms.