It could block the cell cycle at the G2/M phase and induce apoptosis through the activation of p53 and PTEN, further promoting the expression of Bax and Cyt-C.175 It was also found that indolizine derivatives, compound 3, and resveratrol derivative, trans-3, 5, 4′-trimethoxystilbene (TMS), promoted the activation of p53, causing the apoptosis of cancer cells.176,177 TMS cotreatment with TRAIL could reverse the resistance to apoptosis in cells.177. The gene discussed is TNFSF10; the disease is cancer.