Small-molecule compounds activated autophagy via the blocking of the NF-κB pathway to exert an antitumor biologic effect.270 Studies conducted by Zhu et al. demonstrated that olanzapine-induced autophagy via the suppression of the NF-κB pathway also had an inhibitory effect on the MGMT-positive gene, thus leading to the inhibition of proliferation.271 Camptothecin (CPT) was shown to promote esophageal cancer cells’ protective autophagy via the suppression of neddylation, the accumulation of IκBα, and the blockade of the NF-κB pathway. Here, NFKB1 is linked to esophageal cancer.