CXCL8 and neoplasm: The inducements of NETosis formation in malignant tumors include tumor cell colony-stimulating factor (G-CSF), and endothelial cell IL-8.408 Overexpression of G-CSF in tumors can increase the number of neutrophils in the blood, produce ROS and cause the formation of nets.406 Pancreatic cancer (PACA) cells can directly or indirectly induce the formation of nets.409 NETosis exists in animal models and tumor patients’ blood and tumor tissues.