P62-keap1-nrf2 pathway plays an important role in protecting HCC cells from ferroptosis by upregulating ROS-related genes.477 Alkaloid trigonelline reverses drug resistance by inhibiting Nrf2 in vitro and tumor xenotransplantation model, thus increasing the anti HCC activity of erastin and sorafenib477 (Table 17). This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.