In mammals, the FoxO family includes FoxO1, FoxO3, FoxO3, and FoxO6, which act as transcription factors by binding to target DNA through the forkhead domain to activate or inhibit downstream genes, thus affecting the occurrence and development of cancer.262 FoxO proteins could participate in the cell autophagy process to regulate cancer growth and metastasis. This evidence concerns the gene FOXO3 and cancer.