Metformin or pyroptosis inducer activates mir-497 by targeting the mir-497/PELP1 axis, inhibits PELP1 expression, increases the level of cleaved GSDMD, induces pyroptosis in ESCC, and improves the prognosis of ESCC.189 A new antitumor molecule 2-(alpha-naphthoyl) ethyltrimethylammonium Iodide (α-NETA) induces pyroptosis in different epithelial ovarian cancer (EOC) cell lines through GSDMD/ caspase-4 pathway and reduces the size of EOC tumor in mice. The gene discussed is PELP1; the disease is esophageal squamous cell carcinoma.