It has been reported that the expression level of c-FLIP is elevated in colorectal cancer,330 and the c-FLIP isomer is involved in switching apoptosis and necrotic cell death.331 The c-FLIP isomer in ribosomes determines whether cell death occurs ripk3 mediated bad apoptosis or caspase-dependent apoptosis. This evidence concerns the gene RIPK3 and colorectal cancer.