FOXO3 and neoplasm: The combination of gefitinib and a HIF-1α inhibitor, YC-1, could significantly inhibit autophagy, as well as acquired resistance could be overcome.267 WX20120108, as a novel IAP inhibitor, triggered autophagy in HeLa and MDA-MB-231 cells via upregulating the FOXO3 gene and promoting ROS production.268 Furthermore, in an acidic microenvironment, FOXO3 could trigger autophagy by enhancing the expression of LC3-II and Beclin-1 to inhibit tumor cell growth.269