Studies have shown that NLRP3 inflammasome plays an important role in the aggregation of myeloid-derived suppressor cells (MDSC) and the inhibition of antitumor T cell immune response after DC immunization.336 NLRP3 in tumor-associated macrophages drives the polarization of immunosuppressive CD4+ T cells in the tumor immune microenvironment of pancreatic ductal adenocarcinoma through IL-1.337 In addition, the production of IL-22 depends on the activation of NLRP3 inflammatory bodies and the subsequent release of IL-1 from immune cells. The gene discussed is CD4; the disease is neoplasm.