TF and neoplasm: The modified transferrin on the lipid layer further promotes the endocytosis of MOF.482 The upregulated TfR expression on the surface of various tumor cells not only provides a natural advantage for more effective iron-mediated iron endocytosis, but also provides a target for therapeutic drug delivery.483 PL is loaded as a ferroptosis inducer in an iron-containing MOF coated with a dope pH-sensitive lipid layer decorated with transferrin.