For example, AZD2014, as a dual mTOR inhibitor, could suppress proliferation and induce autophagy to sensitize thyroid undifferentiated carcinoma (ATC) cells to paclitaxel (PTX).232 Another novel PI3K/Akt/mTOR inhibitor, W922, was shown to attenuate the growth of CRC cells via the induction of autophagy and when treated in combination with chloroquine, caused a large production of apoptotic cells.233 Chen et al. synthesized a quinazolinyl-arylurea derivative, compound 7j, which possessed a lower IC50 value and good selectivity. The gene discussed is MTOR; the disease is colorectal carcinoma.