Knockdown of GSDMD can block IL-1β secretion and convert pyroptosis into apoptosis, thereby promoting tumor cell killing.340 It has been studied to genetically engineer GSDMD by inserting other protease sites or Caspase-3/-7 cleavage sites between the N-terminal and C-terminal domains of GSDMD, which can also convert apoptosis into pyroptosis.341 Interestingly, the expression of GSDMD in gastric cancer cells was lower than that in adjacent normal tissue cells, which may promote the proliferation of cancer cells. The gene discussed is CASP3; the disease is cancer.