Tumor cells such as diffuse large B-cell lymphoma and renal cell carcinoma have been found to be very sensitive to ferroptosis regulated by GPX4,43 and some drug-resistant tumor cells are also highly dependent on GPX4 to maintain their own survival.374 Therefore, GPX4 is a new target for some tumor therapy. This evidence concerns the gene GPX4 and hereditary clear cell renal cell carcinoma.