GPX4 and cancer: Compound 7j regulated PI3K/Akt/mTOR/ULK1 and Sxc(-)/GPX4/ROS pathways to induce autophagy and ferroptosis of cancer cells at high concentrations while inducing apoptosis at low concentrations.234 It had been reported that some active substances of traditional Chinese medicine had strong antitumor effects, such as Tanshinone IIA (Tan IIA), 20(S)-ginsenoside Rh2 (20 (S)-GRh2), could induce cancer cell cycle arrest and autophagy by inhibiting PI3K/Akt/mTOR pathway, accompanied by increased expression of LC3-II protein235,236 (Table 7).