This effect was induced by the suppression of ULK1.215 Phloretin (PH) effectively inhibited cytoprotective autophagy via the downregulation of the mTOR/ULK1 pathway, further restoring the sensitivity of breast cancer cells to chemotherapeutic drugs.216 Additionally, the research showed that bromodomain and extraterminal domain (BET) inhibitor, JQ1, was considered a hopeful epigenetic agent for the treatment of various tumor types. Here, ULK1 is linked to breast carcinoma.