TP53 and cancer: This study also revealed the physiological function of entosis, found a new mechanism of abnormal cell clearance outside the regulation of the cell cycle, and revealed a new pathway for the p53 gene to maintain epithelial homeostasis and inhibit tumorigenesis at the cell level; On the one hand, it enriches the connotation of the existing mitotic surveillance mechanism; On the other hand, it expands the extension of entosis as a cell death mechanism involved in important biological processes of cancer.402