A natural flavone compound, 5,3′-dihydroxy-3,6,7,8,4′-pentamethoxyflavone (PMF), was reported to induce an intrinsic apoptotic pathway in MCF-7 cells via enhancing the expression of Bax, Cyt-C, and PARP-1, decreasing the Bcl-2 level.96 Some other natural products, like Tracheloside (TCS) and Deoxypodophyllotoxin (DPT), could significantly inhibit the growth of CRC cells.97,98. This evidence concerns the gene BCL2 and colorectal carcinoma.