It could enhance the degradation of anti-apoptotic protein Mcl-1 via the inhibition of the PI3K/Akt/mTOR signaling pathway, thus promoting the apoptotic pathways in SKOV3 cells.195 1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one (EB30) was a curcumin analog that could block the cell cycle and activate ROS production, which induced lung cancer cells apoptosis by inhibiting the PI3K/Akt pathway and activating the ERK1/1 pathway.196 Apigenin 7-O-glucoside (AGL) was shown to trigger apoptosis of HeLa cells via the inhibition of the PTEN/PI3K/Akt pathway in a concentration-dependent manner.197. The gene discussed is AKT1; the disease is lung cancer.