It could upregulate extrinsic apoptosis proteins expression like Fas, FasL, and DR4, as well as induce autophagy by increasing the beclin-1 and p62 proteins.60 Imipramine was a tricyclic antidepressant that triggered extrinsic apoptosis by upregulating FasL and y activating caspase 8/3 in glioblastoma cells. The gene discussed is SQSTM1; the disease is glioblastoma.