RIPK3 may be involved in early tumor growth through enteritis mouse model experiments.300 MLKL is also downregulated in pancreatic and cervical squamous cell carcinomas, where low levels of MLKL in plasma predict poor prognosis in pancreatic and ovarian cancers.301 Altogether, this information provides research directions for studying necrotic proteins in tumor development. The gene discussed is RIPK3; the disease is neoplasm.