PARP1 and skin cancer: Existing studies have shown that parthanatos is closely related to tumorigenesis and development.387 A study conducted microarray analysis on the expression of the PARP-1 gene in more than 8000 tumor samples.388 The results showed that the expression level of PARP-1 in breast cancer, ovarian cancer, endometrial cancer, lung cancer, skin cancer, and non-Hodgkin’s lymphoma was higher than that in the same amount of normal tissues, indicating that parthanatos was closely related to the above tumors.