SIRT5 and breast carcinoma: Sirt5 expression ensures the survival of breast cancer cells and restores their viability upon the knock-down of ATF4. Together, these results highlight a pro-survival mTORC2-dependent signaling pathway that culminates in the sustained expression of ATF4 and the upregulation of its transcriptional target Sirt5 to promote adaptive compensation to metabolic and oxidative challenges.