In summary, these observations are consistent with the activation of the mTORC2-PKC-Nrf2-ATF4-Sirt5 pathway in LN229 glioblastoma cells upon nutrient deprivation, as well as demonstrate the potential of utilizing the bimodal RNA transcript signature that we observe to identify cancer cells where this signaling pathway may play an essential role in their survival. This evidence concerns the gene NFE2L2 and cancer.