Notably, after 1 and 6 months of infection, both DLC1+ and MIST1+ cell counts were reduced in PMSS1 WT infected animals vs. littermates receiving the isogenic CagE-deficient mutant (after 1 month) or were uninfected (Fig. 2C), indicating a negative impact of CagE/T4SS-mediated injection of CagA on the expression of both markers. This evidence concerns the gene S100A8 and infection.