Moreover, during NASH, hepatocytes upregulate the main neutrophil recruiting chemokines (CXCL1 and IL-8),375 and neutrophil infiltration around the lipotoxic hepatocytes is considered a hallmark of NASH.376,377 Neutrophil abundance correlates with the degree of steatosis and fibrosis. The gene discussed is CXCL1; the disease is metabolic dysfunction-associated steatohepatitis.