The percentage of NAFL/NASH Chinese patients with Hp 2-2 allele is much higher than that of western patients (65.71% vs. 36%, respectively), suggesting that Chinese patients may better benefit from vitamin E treatment.285 In the long term, vitamin E use is associated with some potential risks such as prostate cancer, stroke, and mortality.283 However, due to the differences in the use form of vitamin E and the analysis methods, the conclusions of the current study are uncertain regarding the assessment of risk. This evidence concerns the gene HP and metabolic dysfunction-associated steatohepatitis.