PPARA and metabolic dysfunction-associated steatohepatitis: PPARα is the primary regulator of hepatic fat catabolism during fasting.125 It has been demonstrated that deletion of PPARα promoted NAFL/NASH and hepatic inflammation in mice.126 It was observed that lipid accumulated massively in the liver of global PPARα knockout (Ppara−/−) mice fed with HFD.127 Hepatic steatosis was reduced in hepatocyte-specific PPARα deficient mice compared to Ppara−/− mice, probably due to increased FAO in other extrahepatic tissues like brown adipose tissue, muscle, and heart.128