CD8A and cancer: Using the CIBERSORT algorithm, we found that in most cancer types SAAL1 expression was positively correlated with the frequency of favorable tumor-infiltrating immune cells (i.e., favoring anti-tumor immunity) such as activated CD4+ memory T cells, activated NK cells, M1 macrophages, and cytotoxic CD8+ T cells, and negatively correlated with unfavorable tumor-infiltrating immune cells (i.e., favoring suppression of anti-tumor immunity) such as regulatory T cells (Tregs), resting mast cells, and resting CD4+ memory T cells (Figure 6A).