Since the potential involvement of SAAL1 in the pathogenesis and progression of other cancer types, as well as its significance in cancer immunotherapy, remain unexplored, in this study we conducted a pan-cancer analysis of SAAL1 expression and its association with TME immunological characteristics, sensitivity to chemotherapy agents, response to anti-PD-L1 immunotherapy, and patient prognosis. The gene discussed is SAAL1; the disease is cancer.