In this paper, we sort out a comprehensive bioinformatics analysis of the m6A “readers” (including YTHDC1, YTHDC2, YTHDF1, YTHDF2, YTHDF3, IGF2BP1, IGF2BP2, IGF2BP3, HNRNPA2B1, HNRNPC, and NKAP) in HCC. This evidence concerns the gene YTHDF2 and hepatocellular carcinoma.