Our results showed that the mRNA expression level of the common m6A “readers” including YTHDC1, YTHDC2, YTHDF1, YTHDF2, YTHDF3, IGF2BP1, IGF2BP2, IGF2BP3, HNRNPA2B1, HNRNPC, and NKAP were highly expressed in HCC. The gene discussed is YTHDF1; the disease is hepatocellular carcinoma.