In this paper, we sort out a comprehensive bioinformatics analysis of the m6A “readers” (including YTHDC1, YTHDC2, YTHDF1, YTHDF2, YTHDF3, IGF2BP1, IGF2BP2, IGF2BP3, HNRNPA2B1, HNRNPC, and NKAP) in HCC. The gene discussed is YTHDF3; the disease is hepatocellular carcinoma.