Our results showed that the mRNA expression level of the common m6A “readers” including YTHDC1, YTHDC2, YTHDF1, YTHDF2, YTHDF3, IGF2BP1, IGF2BP2, IGF2BP3, HNRNPA2B1, HNRNPC, and NKAP were highly expressed in HCC. Here, YTHDC2 is linked to hepatocellular carcinoma.