For anti-inflammatory cytokines, a relatively homogenous pattern was seen; IRF5 CKO induced a significant increase in both IL-4 and IL-10 levels (Figure 5F, 5G), and IRF4 CKO caused significant reduction in IL-4 (Figure 6F) and a decrease trend in IL-10 (Figure 6G) level, in stroke groups. The gene discussed is IRF4; the disease is Stroke.