Variants in genes such as corneodesmosin (CDSN) and small nuclear ribonucleoprotein polypeptide E (SNRPE) usually result in hypotrichosis as an isolated finding, whereas variants in CDH3 gene lead to hypotrichosis as a part of a syndrome like hypotrichosis simplex with juvenile macular dystrophy (HJMD; OMIM #601553) or ectodermal dysplasia, ectrodactyly and macular dystrophy (EEM; OMIM #225280) (Indelman et al. 2005; Kjaer et al. 2005; Hua et al. 2021; Pan et al. 2021). The gene discussed is CDSN; the disease is hypotrichosis.