Moreover, overexpression of SQLE obviously suppressed phosphorylation of ERK in GBM, but down‐regulation of the phosphorylation of ERK with KO‐947, a tested ERK inhibitor, has no influence on SQLE expression, suggesting that SQLE may inhibit chemoresistance in GBM via MARK/ERK pathway by down‐regulated the phosphorylation of ERK (Figure 4C,D). This evidence concerns the gene MARK1 and glioblastoma.