Then, a PPI network of these moleculars that co‐expressed with SQLE was created, and it was found that DCX, NXPH1, KCND2, SYT13, HES5, and PAK3 were mainly related to the modulation and function of the SQLE differentially expressed in GBM (Figure 7A). The gene discussed is PAK3; the disease is glioblastoma.