In this study, we demonstrated that SQLE had the most significant correlations with tumor‐infiltrating lymphocytes (such as Mast, Monocyte, MDSC, and Act_DC), immunostimulators (such as TNFSF13, CD86, C10orf54, and CD48), immunoinhibitors (such as IL10, CD244, HAVCR2, and PDCD1LG2), and MHC molecules (such as HLA–DMB, HLA–DRA, HLA–DMA, and HLA–DOA). This evidence concerns the gene PDCD1LG2 and neoplasm.