As a protein kinase R-like endoplasmic reticulum kinase (PERK) inhibitor, GSK2606414 can significantly inhibit the PERK dependent signaling pathway in human colorectal adenocarcinoma cell line HT-29 and human neuroblastoma cell lines SH-SY5Y, which can promote apoptosis by inducing endoplasmic reticulum stress [110, 111]. This evidence concerns the gene EIF2AK3 and neuroblastoma.