The results revealed that high expression of LARS was significantly negatively correlated with the prognosis of osteosarcoma patients, and low expression of DNAJC17 (DnaJ Heat Shock Protein Family (Hsp40) Member C17) was significantly negatively correlated with the prognosis of osteosarcoma patients, Next, we used the LASSO analysis of the tenfold cross-validation to analyze LARS and DNAJC17 genes (Fig. 3B), and constructed the risk score model that included LARS and DNAJC17 genes (Fig. 3C). The gene discussed is DNAJC17; the disease is osteosarcoma.