The results indicated that LARS expression is significantly negatively correlated with the infiltration levels of Monocytic lineage (R = − 0.42, p < 0.01), T cells (R = − 0.35, p < 0.05), and Fibroblasts (R = − 0.31, p < 0.05) in osteosarcoma (Fig. 8B). Here, LARS1 is linked to osteosarcoma.