The limitation of the fact that CellSearch® detects EpCAM+ cells leading to the loss of EpCAM-cells has been improved in other methods by combining different specific tumor markers, including EGFR, cytokeratin, HER2, folic acid receptors (FRs), and recombinant VAR2CSA (rVAR2) [16, 86–88]. Here, EPCAM is linked to neoplasm.