In the training cohort (GSE37642-GPL96), through univariate Cox regression analysis, ten out of the 45-gene set including ARTN, IL5RA, LTK, MYRF, SERPINI2, SLC9A3R2, TPPP3, TPSAB1, TPSB2 and TUBB3, were found to be associated with the OS of patients with AML (Additional file 2: Fig. S2). This evidence concerns the gene SERPINI2 and acute myeloid leukemia.