Figure 4A shows the top 10 KEGG signalling pathways as follows: hsa05323, rheumatoid arthritis; hsa04064, NF-kappa B signalling pathway; hsa04668, TNF signalling pathway; hsa04620, Toll-like receptor signalling pathway; hsa04621, NOD-like receptor signalling pathway; hsa05134, Legionellosis; hsa04380, osteoclast differentiation; hsa04657, IL-17 signalling pathway; hsa05417, lipid and atherosclerosis; and hsa04061, viral protein interaction with cytokine and cytokine receptor. The gene discussed is TNF; the disease is atherosclerosis.