IDO1 and neoplasm: We also found that ANK1 (P = 0.0018), IL4I1 (P = 1.2e−12), IDO1 (P = 0), IFNG (P = 0)and MAPK12 (P = 2.2e−12; Fig. 4G) are positively correlated with PD-L1 expression in CRC cancer which has been reported to be associated with worse prognosis and counteract effect of tumor-infiltrating lymphocytes [28, 29].