We found that significant differences in ANK1 and MAPK12 expression were detected between responders (no resid ualhistological evidence of tumor) and non-responders (with residual tumor tissue) after chemotherapy (Mann–Whitney test, FC = 1.3, P = 0.017 for ANK1; FC = 0.83, P = 0.033 for MAPK12), suggesting their correlation to chemotherapy resistance in colorectal cancer. This evidence concerns the gene ANK1 and colorectal cancer.