The SMIM30 has a secondary structure of ɑ-helix and is an important adapter for membrane anchoring, and activation of tyrosine kinase SRC/YES1, which activates the MAPK signalling pathway and promotes the development of liver cancer; (3) circRNA: Circ-AKT3 encoded AKT3-174aa through overlapping starting and terminating cipher subcodes. Here, SMIM30 is linked to liver cancer.