We screened out the key target SLC2A10 in GBM, further obtained the verified ceRNA mechanism through multiMiR, and found that LINC02381 was significantly highly expressed in GBM, and confirmed the expression of SLC2A10 and LINC02381 in GBM, LINC02381/hsa-miR-27a-3p/SLC2A10 has a potential ceRNA mechanism in GBM. This evidence concerns the gene SLC2A10 and glioblastoma.